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Species » C. elegans(Genome assembly: WBcel235)

Expression cluster » [cgc6390]:mixed_oogenesis-somatic

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  • Comments on [cgc6390]:mixed_oogenesis-somatic (0)

  • Overview

    [cgc6390]:mixed_oogenesis-somatic

    Species:
    Caenorhabditis elegans
    Attribute of Microarray experiment:
    [cgc6390]:L4_WT_vs_glp-4
    [cgc6390]:adult_WT_vs_glp-4
    [cgc6390]:fem-3(gf)_vs_fem-1(lf)
    [cgc6390]:glp-4_hermaphrodites_vs_glp-4_him-5_males
    [cgc6390]:hermaphrodites_vs_him-5_males
    [cgc6390]:him-5_vs_glp-4_him-5
    WormBase ID:
    [cgc6390]:mixed_oogenesis-somatic
    mixed oogenesis/somatic

    Algorithm:

    Comparisons were made between genotypes by subtracting the mean log value of one ratio from another, and the significance of the difference was evaluated using Student t-test for two populations. For the fem-3(gf) versus fem-1(lf) direct comparison, authors performed the same analysis, except they used a Students t-test for one population. Author chose a combination of a twofold difference with a t value exceeding 99% confidence (P < 0.01), because these criteria allowed the inclusion of essentially all genes that had previously been identified as germline-enriched in a wt/glp-4 hermaphrodite comparison. Additionally, requiring a twofold difference reduced false positives, as the number of genes with two-fold difference and a P<0.01 only included ~100 genes more than with P < 0.001, and almost all genes showed germline expression by in situ hybridization.

    Remarks:

    These are gene expression categories discussed in the paper.

  • Associations

    No associations data for [cgc6390]:mixed_oogenesis-somatic
    Anatomy Terms:
    Life Stages:
    GO terms:
    Processes:

  • Regulation

    No regulation data for [cgc6390]:mixed_oogenesis-somatic
    Regulated by Gene:
    Regulated by Treatment:
    Regulated by Molecule:

  • References

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      • Journal article

      1

    1 reference found
    Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans.
    Journal article
    Development
    2004

    We performed a genome-wide analysis of gene expression in C. elegans to identify germline- and sex-regulated genes. Using mutants that cause defects in germ cell proliferation or gametogenesis, we identified sets of genes with germline-enriched expression in either hermaphrodites or males, or in both sexes. Additionally, we compared gene expression profiles between males and hermaphrodites lacking germline tissue to define genes with sex-biased expression in terminally differentiated somatic tissues. Cross-referencing hermaphrodite germline and somatic gene sets with in situ hybridization data demonstrates that the vast majority of these genes have appropriate spatial expression patterns. Additionally, we examined gene expression at multiple times during wild-type germline development to define temporal expression profiles for these genes. Sex- and germline-regulated genes have a non-random distribution in the genome, with especially strong biases for and against the X chromosome. Comparison with data from large-scale RNAi screens demonstrates that genes expressed in the oogenic germline display visible phenotypes more frequently than expected.

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